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Vaccine Bivalent Real World
About Vaccine Bivalent Real World
Real world effectiveness data for bivalent COVID boosters showed moderate protection against symptomatic infection that waned over 3 to 6 months. CDC studies estimated moderate added protection against symptomatic infection in the first months after a bivalent booster, with higher protection against hospitalization. The data informed policies on periodic updated vaccination. However, some researchers questioned whether repeated boosting with the same spike protein was the optimal strategy. Immune imprinting from original vaccination may limit the effectiveness of updated boosters. The concept of annual COVID vaccination similar to influenza was adopted by most countries. However, the optimal frequency and composition of COVID boosters remains uncertain. Nasal vaccines and vaccines targeting conserved proteins may provide more durable protection than repeated mRNA boosters.
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